This research project material is available: EXTRACTION AND STUDY THE EFFECT OF HEAT ON CAFFEINE EXTRACTED FROM KOLANUT.
The study could be of great importance inidentifying and evaluating the regions of the brain that may be affected by Cola nitida, give insight to people, especially students on the effect of the plant on memory, cognition, anxiety-like behaviours and its relationship with biochemical parameters. Despite reported evidence of neurodegeneration that Cola nitida has on the cerebellum (Buraimoh et al., 2014), traditional, cultural and social use in our environment is still on the rise. Therefore, there is need to investigate further; the effect of Cola nitida on other parts of the nervous system, such as the cerebral cortex and hippocampus. Cola nut is a caffeine-containing nut of evergreen trees of the genus Cola, primarily of the species Cola acuminata and Cola nitida. It is one of the most common chewable nut in Nigeria. It is a central nervous system stimulant used in folk medicine as an aphrodisiac, an appetite suppressant, to treat migraine headache and indigestion. The aim of the present study was to investigate the possible effects of Cola nitida extracts on the cerebral cortex, hippocampus and some biochemical parameters. Forty (40) adult Long Evans rats of both sexes, with average weight of 210-230grams were randomly divided into four groups: A (control) = four rats (administered normal feed and distilled water);B= caffeine fraction group containing three sub groups of four rats each, B1, B2 and B3 were administered with di-chloromethane caffeine fractionof 19.2, 38.4 an
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