EFFECT OF CAFFEINE ON BLOOD GLUCOSE AND LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC WISTAR RATS
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EFFECT OF CAFFEINE ON BLOOD GLUCOSE AND LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC WISTAR RATS
PROJECT TOPICS AND MATERIALS ON EFFECT OF CAFFEINE ON BLOOD GLUCOSE AND LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC WISTAR RATS
Abstract
Diabetes mellitus is characterized by hyperglycemia. Caffeine has
been suggested to be capable of disrupting glucose metabolism. The
effects of caffeine on blood glucose level and on lipid profile of
alloxan induced diabetic Wistar rats were studied. The effect of
caffeine by determining the blood glucose levels at intervals of 30mins,
1hour and 2hours respectively following administration of caffeine.
Caffeine at a dose of 25 mg/kg and 100 mg/kg produced significant
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at="" be="" blood="" body="" caffeine="" can="" causes="" changes=""
compared="" comparison="" concluded="" control.="" control=""
dependent.="" diabetic="" difference="" dose="" duration=""
experiment="" found="" glucose="" group.="" groups.="" groups=""
hours="" in="" increase="" increases="" indices="" it="" kg="" lasted=""
level="" levels="" lipid="" may="" mg="" no="" of="" on="" other=""
produce="" profile="" rats.="" rats="" received="" results="" showed=""
significant="" significantly="" span="" suggest="" that="" the=""
there="" therefore="" these="" those="" to="" triglyceride=""
triglycerides="" was="" weeks="" weights="" wistar="" with="">
CHAPTER ONE
1.0 INTRODUCTION
1.1 Diabetes Mellitus
Excessive urine excretion is one of the major symptoms of diabetes.
The most common form of diabetes is diabetes mellitus, a metabolic
disorder in which there is an inability to oxidize carbohydrate due to
disturbances in insulin function. Diabetes mellitus is characterized by
elevated glucose in the plasma and episodic ketoacidosis. Additional
symptoms of diabetes mellitus include polydipsia, glucosuria, polyuria,
lipemia and hunger (King et al., 1998; WCPD, 2012).
Diabetes mellitus is a heterogeneous clinical disorder with
numerous causes. Two main classifications of diabetes mellitus exist,
idiopathic and secondary. Idiopathic diabetes is divided into Type 1
diabetes (IDDM) and Type 2 diabetes (NIDDM) (WHO, 2003).
Type 2 diabetes is associated with a cluster of interrelated plasma
lipid and lipoprotein abnormalities, including reduced HDL cholesterol,
a predominance of small dense LDL particles, and elevated
triglycerides. These abnormalities occur in many patients despite normal
LDL cholesterol levels. These changes are also a feature of the insulin
resistance syndrome (also known as the metabolic syndrome), which
underlies many cases of type 2 diabetes. In fact, pre-diabetic
individuals often exhibit an atherogenic pattern of risk factors that
includes higher levels of total cholesterol, LDL cholesterol, and
triglycerides and lower levels of HDL cholesterol than individuals who
do not develop diabetes (Krauss, 2004).
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Excessive urine excretion is one of the major symptoms of diabetes. The most common form of diabetes is diabetes mellitus, a metabolic disorder in which there is an inability to oxidize carbohydrate due to disturbances in insulin function. Diabetes mellitus is characterized by elevated glucose in the plasma and episodic ketoacidosis. Additional symptoms of diabetes mellitus include polydipsia, glucosuria, polyuria, lipemia and hunger (King et al., 1998; WCPD, 2012).
Diabetes mellitus is a heterogeneous clinical disorder with numerous causes. Two main classifications of diabetes mellitus exist, idiopathic and secondary. Idiopathic diabetes is divided into Type 1 diabetes (IDDM) and Type 2 diabetes (NIDDM) (WHO, 2003)... physiology project topics
EFFECT OF CAFFEINE ON BLOOD GLUCOSE AND LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC WISTAR RATS