THE BEHAVIORAL TERAOGENIC EFFECT OF CIMETIDINE ON THE OFFSPRINGS OF ALBINO RATS
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THE ROLE OF SEX HORMONES
During childhood, the
capacity of sexual response and the experience of sexual pleasure as
well as the potential for orgasm exists at least in a proportion of
children whether this apparently variable potential among
childrenreflects different learning experiences during childhood,
different opportunities for realizing the potential or different gentile
influences is not known. The importance of gonadal hormones in
particular testosterone, in organizing early brain development and
function has been discussed earlier. During childhood, gonadal steroid
hormones are title in evidence, but from the ages of 9 or 10 years they
start to increase as the child approaches puberty from there on we have
to consider the activating role of those hormones on sexuality and the
impact they have on sexuality, and the impact they have on sexuality,
and the impact they have on sexuality during three stages of the life
course around puberty and during early adolescence during adulthood
until muddle age, and during the later years.
An adult male’s
continued interest in sex depends on he’s having a normal level of
circulating testosterone. If an otherwise normal male has his
testosterone lowered by testicular suppressive drugs, he experiences a
decline in sexual interest, which returns when the process is reversed.
In case of testicular impairment (primary or secondary hypogonadison).
When testosterone level fall below normal range almost all males
experience a decline in sexual interest and capacity for ejaculation.
This is reversed by testosterone replacement the raphy. This is a
robust, predictable finding across a substantial number of
placebo-controlled studies. A similar pattern is observed with
spontaneous erection during sleep, or nocturnal penile tumescence, which
decline and return with testosterone withdrawal and replacement these
erections are interesting manifestations of the sexually arousability of
the brain uncomplicated by cognitive processes, and this evidence
clearly points to the role of testosterone in central sexual arousal
mechanism it is important to emphasis, however, that normal levels of
testosterone are necessary but not sufficient for normal levels of
sexual desire. These are the factors which can inhibit or alter sexual
desire in the presence of normal testosterone levels.
The role of
testosterone the become less clear as men get older there is a normal,
but variable, tendency for tester one levels of decline on men beyond
the fifth decade, and this is often accompanied by an age-related
decline in sexual interest. This is sometimes referred to
inappropriately as the “male menopause” However, there is no clear
evidence that that this pattern can be reversed by testosterone
replacement. It is possible that there is a decline in responsiveness to
testosterone in addition to a fall in the hormone level (Schiavs,
There is also a common (though variable) age-related decline
in erectile responsiveness, such that are men get older erections
develop less consistently and are less strong and less well-sustained.
The mechanisms for this are not well understood but may be related to
change in neuro transmitter responsiveness in erectile tissues (Cerner
and Chirst, 2000).
THE SIDE EFFECTS OF DRUGS
the complexity of the brain, and its mechanism of control, it is not
surprising that anyone mechanism in involved in a variety of different
response patterns. Thus mechanisms relevant to control to sexual
response may also be relevant to control of other motivated behaviours
such as eating or aggressive behaviour for this season it is difficult
to develop drugs which selectively influence specific aspects of brain
function. As a consequence, drugs developed for one purpose have other
unwanted or unintended side effect. Sexual side effects of drugs aimed
at the as are not uncommon although biochemical mechanisms in the CNS
are enormously complex, as previously discussed, we can consider drug
effects which are likely to be predominantly central and those
repdominantly peripheral. We can also consider drugs which have
serotonergic, noradrenergic, and dopaninergic effects. The best examples
are modery anticlegressanys which involve inhibition of serotonin
re-take (SSRI’S such as flutxcline; Rosen, lane, & menace (2001).
Such drug commonly inhibit organism in women or decay ejaculation in
men, and are used to treat problems of repaid ejaculation.
THE BEHAVIORAL TERAOGENIC EFFECT OF CIMETIDINE ON THE OFFSPRINGS OF ALBINO RATS
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