CELL SURFACE INTERACTION ON A MULTI - SCALE


2,182 marked this research material reliable.
Call or whatsapp: +2347063298784 or email: info@allprojectmaterials.com
Department: physical science project topics | Type: Project Topics | Project Topics and Materials | List of Project Topics | Research Project Materials | Journals | Thesis | Articles | Online Project Materials | Business Plan | Final year project topic | Format: Ms Word and PDF | Attribute: Documentation Only | Pages: 50 Pages | Chapters: Complete Research work from Chapter 1 to 5; All chapters | Inclusive: Abstract, Preliminary Pages, Table of Contents and Appendices | Cost: ₦ 5,000.00


CELL SURFACE INTERACTION ON A MULTI - SCALE

PROJECT TOPICS AND MATERIALS ON CELL SURFACE INTERACTION ON A MULTI - SCALE


ABSTRACT

The increasing rate of cancer patients worldwide, and especially Africa has led to numerous efforts to battle it. One approach to this has been localized drug delivery to reduce the quantity of drugs needed for therapeutic effect. Poly-di-methyl-siloxane (PDMS) is an elastomer with much focus on it as a microfluidic device. PDMS is one polymer of choice for localized drug delivery due to its biocompatibility, transparency, and ease of fabrication. However, its highly hydrophobic nature does not allow it to be used without modification. This work presents results of experimental and computational methods for PDMS surface modification. Also computational results of shear assay model for the effects on surface modification on cell adhesion is present. Modifying the surface of the PDMS was done by varying the mix ratio and curing temperatures after fabrication. The results from the experiment shows that low base to curing agent ratio and increasing curing temperature gives a highly stiff PDMS. Also, the PDMS treatment via boiling water and Ultraviolet Ozone (UVO) methods makes it hydrophilic with the generation of hydroxyl (OH) group on the substrates. These studies provided understanding of cell-surface interaction on a multi-scale. Morphological studies with Scanning Electron Microscope (SEM) reveal a layer and textured featured formed on UVO treated and PLGA coated PDMS. Shear assay model showed that cells on modified PDMS surface low energy release rate on application of shear load. This signifies that cells adhered to the modified surfaces better, thus could not be easily detached.



1.0 CHAPTER ONE

1.1 INTRODUCTION

The treatment of injury, disease and congenital malformation from traditional to scientific has been part of the human experience. Better ways are sought to improve human life. One disease that is currently taking human lives is cancer. Cancer is second only to cardiovascular disease [1, 2], and with current trends is likely to become the leading cause of death globally by 2030 [1].

In a quest to battle this globally threatening disease, research is being done to improve on conventional methods of detection and treatment [3-6]. This is to reduce the various side effects that accompany existing methods based on surgical procedures, radiation therapy, including bulk systemic chemotherapy. It is important to explore alternative approaches that can reduce the killing of normal or healthy cells during the cancer treatments.

An emerging field, tissue engineering, which provides an approach for the repair and fabrication of tissue from living cells [7] offers a better approach to cancer treatment. Soft tissue engineering plays a vital role in the treatment of cancer through implantable device. Implantable cancer treatment device enables localized drug delivery [6, 8]. This reduces the quantity of drug that is needed to have therapeutic effect significantly. Thus potential side effects of localized cancer drug delivery become much less than bulk systemic chemotherapy.

In localized cancer drug delivery, one polymer which has been used as a packaging material for controlled drug release is poly-di-methyl-siloxane (PDMS) [9]. PDMS is a biocompatible polymer, according to the United States Food and Drug Administration (US FD) and after some toxicity studies [10, 11], it has been approved for applications in implantable biomedical devices in humans [12, 13]. The challenge, however, lies in the physiochemical properties of PDMS surfaces, which may affect proper cell function, leading to poor integration of biomedical implants.

Even though some general correlations between the physiochemical properties of a given surface and its performance as a support for cell adhesion and growth have been established, there is limited understanding of the multi-scale interactions that lead to cell adhesion. There is therefore the need to study the effects of cell adhesions at multiple scales (nano, micro and meso).

1.1.2 Objectives

There are still significant unresolved issues that must be resolved to enable the design of improved adhesion between cells and implantable drug delivery device [15, 16]. These must be resolved to ensure improved integration between PDMS and biological cells/tissue. This will be done by the fabrication of PDMS and the engineering PDMS surfaces to make them more suitable for applications in an implantable cancer treatment device. This will be achieved by the use of surface modification and extra-cellular matrix (ECM) coating techniques.

DOWNLOAD COMPLETE WORK FOR CELL SURFACE INTERACTION ON A MULTI - SCALE


Additional Information

  • The Project Material is available for download.
  • The Research material is delivered within 15-30 Minutes.
  • The Material is complete from Preliminary Pages to References.
  • Well Researched and Approved for supervision.
  • Click the download button below to get the complete project material.

Frequently Asked Questions

In-order to give you the best service available online, we have compiled frequently asked questions (FAQ) from our clients so as to answer them and make your visit much more interesting.

We are proudly Nigerians, and we are well aware of fraudulent activities that has been ongoing in the internet. To make it well known to our customers, we are geniune and duely registered with the Corporate Affairs Commission of the republic of Nigeria. Remember, Fraudulent sites can NEVER post bank accounts or contact address which contains personal information. Free chapter One is always given on the site to prove to you that we have the material. If you are unable to view the free chapter 1 send an email to info@researchcub.info with the subject head "FREE CHAPTER 1' plus the topic. You will get a free chapter 1 within an hour. You can also check out what our happy clients have to say.


Students are always advised to use our materials as guide. However, if you have a different case study, you may need to consult one of our professional writers to help you with that. Depending on similarity of the organization/industry you may modify if you wish.


We have professional writers in various disciplines. If you have a fresh topic, just click Hire a Writer or click here to fill the form and one of our writers will contact you shortly.


Yes it is a complete research project. We ensure that our client receives complete project materials which includes chapters 1-5, full references, questionnaires/secondary data, etc.


Depending on how fast your request is acknowledged by us, you will get the complete project material withing 15-30 minutes. However, on a very good day you can still get it within 5 minutes!

What Clients Say

Our Researchers are happy, see what they are saying. Share your own experience with the world.
Be polite and honest, as we seek to expand our business and reach more people. Thank you.

A Research proposal for cell surface interaction on a multi - scale :
Reviews: A Review on cell surface interaction on a multi, scale , cell, surface, interaction project topics, researchcub.info, project topic, list of project topics, research project topics, journals, books, Academic writer.
The increasing rate of cancer patients worldwide, and especially Africa has led to numerous efforts to battle it. One approach to this has been localized drug delivery to reduce the quantity of drugs needed for therapeutic effect. Poly-di-methyl-siloxane (PDMS) is an elastomer with much focus on it as a microfluidic device. PDMS is one polymer of choice for localized drug delivery due to its biocompatibility, transparency, and ease of fabrication. However, its highly hydrophobic nature does not allow it to be used without modification. This work presents results of experimental and computational methods for PDMS surface modification. Also computational results of shear assay model for the effects on surface modification on cell adhesion is present. Modifying the surface of the PDMS was done by varying the mix ratio and curing temperatures after fabrication. The results from the experiment shows that low base to curing agent ratio and increasing curing temperature gives a highly stiff PDMS. Also, the PDMS treatment via boiling water and Ultraviolet Ozone (UVO) methods makes it hydrophilic with the generation of hydroxyl (OH) group on the substrates. These studies provided understanding of cell-surface interaction on a multi-scale. Morphological studies with Scanning Electron Microscope (SEM) reveal a layer and textured featured formed on UVO treated and PLGA coated PDMS. Shear assay model showed that cells on modified PDMS surface low energy release rate on application of shear load. This signifies that cells adhered to the modified surfaces better, thus could not be easily detached... physical science project topics

CELL SURFACE INTERACTION ON A MULTI - SCALE

Project Information

Share Links

Download Post (MsWord)
Download Post (PDF)

Search for Project Topics

Project topics in Departments

How much does it cost to hire a writer in Nigeria?

Looking for Professional Approach and Quality Research Services ?

Estimating the cost of research writing in Nigeria: Freelance writers in Nigeria may charge anywhere from ₦5,000 to ₦50,000 or more per project, depending on the factors mentioned earlier. SEO-focused content may be on the higher end of this range due to the additional skills and research involved. For a more accurate estimate, it's recommended to reach out with us, discuss your specific requirements, and request a quote based on the scope of your project. Prices can vary, so getting personalized quotes will help you determine the cost more precisely.

Undergraduate Project Topics, economics project topics, marketing project topics, business administration project topics, engineering project topics, computer science project topics, banking & finance project topics, education project topics, law project topics, sciences project topics, public administration project topics, political science project topics, mathematics project topics, medical science project topics, mass communication project topics, research projects, geology project topics, marketing project topics, agriculture project topics, Browse Thousands of Final Year Project Topics, hire a writer, Research Works and Materials, Project topics and materials in Nigeria, Undergraduate Project Topics, Research Works and Materials, research topics, research project materials, complete project materials, computer science project material, free project topics, complete projects, accounting topics, small business topics, entrepreneurship topics, project materials, Nigerian undergraduate projects, business administration projects, computer science topics and projects, MBA Nigerian project topics, human resources, small businesses, entrepreneurship projects, economics projects, impacts projects, effect projects, university projects, polytechnic projects, investigate projects, political science projects, mass communication projects, project topics, human resource projects, education projects, French topics, project analysis, French projects, project tips, project abstract, project proposals, project bibliography, project reference, project seminar, forex, TSA, treasury single account, currency, naira, devaluation, undergraduate projects, final project research, marketing project topics, statistics project topics, mathematics project topics, statistics, mathematics, research projects, project thesis, labour force theses, NCE, OND, HND, BTECH, BSC, MBA, MSC, English projects, linguistic project topics, Free Project topics and materials in Nigeria, research topics, reseach project materials, computer science project material, free, complete, accounting topics, small business topics, materials, nigeria projects, business administration projects, computer science topics and projects, MBA nigeria project topics, human resources, small business, entrepreneurship projects, economics projects, impact projects, effects projects, training, budgets, ghana, university, polytechnic, browse Free project materials and topics in Nigeria, accounting and finance project materials, business administration project materials and topics, human resources, entrepreneurship, computer science and engineering project materials and topics, Accounting project topics, Accounting project topics and materials, Agricultural Economics Project Topics and Materials, Agricultural Science Projects topics and materials, All Project topics and materials, Architecture Project topics and materials, Aviation project topics and materials, Banking & Finance Projects topics and materials, Biology project and materials, Building project topics and materials, Business Administration & Management Projects topics and materials, Chemical Engineering Project Topics and materials, Civil Engineering Projects topics and materials, Communication & mass communication art project topics and materials, Computer Engineering Project Topics and materials, Computer Science Projects topics and materials, Criminology project topics and materials, Economics Research Projects topics and materials, Education Project Topics and Materials, Electrical Engineering Projects and materials, English Education & English Language Project topics and materials, Food Science project topics and materials, Geology Project Topics and materials, Guidance Counseling Project Topics and materials, History project topics and materials, Home Economics Project Topics and Materials, Human Resource Projects topics and Materials, Industrial Chemistry Projects topics and materials, Insurance Projects topics and materials, Law project topics and materials, Library and information science project topics and materials, Marine and Transport management project topics and materials, Marketing Projects topics and materials, Mathematics project topics and materials, Medical Sciences Project Topics and materials, Microbiology project topics and materials, Nursing and Midwifery project topics, Nursing and Midwifery project topics and materials, Optometry or nursing project topics and materials, Petroleum Engineering project topics and materials, Pharmacy project topics and materials, Philosophy project topics and materials, Photography project topics and materials, Physical and Health Education project topics and materials, Physiology project topics and materials, Political science project topics and materials, Project topics and materials, Psychology project topics and materials, Random project, Religious and Cultural Studies Project Topics and Materials, Sociology and Anthropology Project topics and materials, Sociology Project Topics and materials, Tourism project topics and materials, Vocational education project topics and materials. Project Topics: List of Project Topics | cell surface interaction on a multi | scale | cell | surface | interaction Project Topics | researchcub.info