Translate this page

prodigiosin encapsulated poly lactide-co-glycolide (plga)-coated ...

PRODIGIOSIN ENCAPSULATED POLY LACTIDE-CO-GLYCOLIDE (PLGA)-COATED STENT FOR CORONARY CARDIOVASCULAR INTERVENTIONS



This research project material is available: PRODIGIOSIN ENCAPSULATED POLY LACTIDE-CO-GLYCOLIDE (PLGA)-COATED STENT FOR CORONARY CARDIOVASCULAR INTERVENTIONS



Download Complete Research Project Material on PRODIGIOSIN ENCAPSULATED POLY LACTIDE-CO-GLYCOLIDE (PLGA)-COATED STENT FOR CORONARY CARDIOVASCULAR INTERVENTIONS



Project Category:
Type: Project Topics | Project Topics and Materials | List of Project Topics | Research Project Materials | Journals | Thesis | Articles | Online Project Materials | Business Plan | Final year project topic| Format: Ms Word| Attribute: Documentation Only| Pages: 50 Pages| Chapters: Complete Research work from Chapter 1 to 5; All chapters | Price: ₦ 5,000.00



Call or whatsapp: +2347063298784 or email: allprojectmaterials.com

Download Post (MsWord)


Download Post (PDF)


Download complete Chapters



PRODIGIOSIN ENCAPSULATED POLY LACTIDE-CO-GLYCOLIDE (PLGA)-COATED STENT FOR CORONARY CARDIOVASCULAR INTERVENTIONS



ABSTRACT

This research focuses on the design of a robust but flexible prodigiosin eluting stent coating for possible coronary cardiovascular implant. When coated with the drug embedded polymer matrix, the stent would be expected to dilate the vessel around the fatty blockages while the drug eluting polymer membrane delivers anti-proliferative drugs over a period of time to prevent the restenosis that otherwise would occur. The goal of this work is to incorporate anti-cancerous drug prodigiosin in the PLGA polymer matrix and then ascertain its release kinetics. In this research, Poly vinyl Pyrrolidone was used as a binder and cross-linker to create adhesion between the metallic stent strut and the drug encapsulated polymer matrix as well as between the polymer and the drug. This work also explores diffusion and degradation phenomena to explain the transport, dissemination, dispersion and absorption of drugs at the interface between the stent and the vessel wall. The expected results will then be discussed for potential applications via the incorporation of these prodigiosin-eluting stents for the treatment of coronary cardiovascular diseases.



CHAPTER ONE

1.0         BACKGROUND AND INTRODUCTION

Cardiovascular disease is currently the leading cause of death in Africa and the world at large, accounting for at least 30% of all death. One of the major causes of cardiovascular disease is arteriosclerosis. It is as a consequence of the build-up of fatty cells and tissues within blood vessels. In most cases, this built-up is not detected until complete blockage which prevents the flow of blood and subsequently leads to heart attack, stroke or death. The objective is to develop prodigiosin embedded polymer-coated cardiovascular stents that will successfully deliver drugs and bioactive agents to blood vessels and treat coronary cardiovascular diseases while at the same time preventing restenosis-the narrowing of the blood vessel after angioplastic procedure. The polymer earmarked for these biodegradable coating is poly lactic-co-glycolic acid (PLGA) because of it biocompatibility and high rate of biodegradation. Over the past decade, drug eluting stents have been used to treat arteriosclerosis. Essentially, the stent dilate the vessel around the fatty blockages while the drug eluting coatings deliver anti-cancer drugs to prevent the restenosis that otherwise would occur. However, the stents remain permanently in the blood vessels after the duration of drug elution. Furthermore, vessel irritation, endothelial dysfunction, vessel hypersensitivity and chronic inflammation at the site of implantation are critical parameters that have attracted serious attention. There is therefore a need for multi-component, multifunctional materials for novel cardiovascular stents whereby, one important function should be degradability of the polymer so that after degradation, a functional vessel wall is regenerated [1].

There is also an equal need for reasonable stent coatings that can degrade gradually and be absorbed slowly by the body without creating the afore-mentioned adverse side effects.

1.1         STATEMENT OF THE PROBLEM

Cardiovascular disease (CVD) is a result of the disorder of the heart and blood vessels. Atherosclerosis, the main cause of coronary artery disease (CAD), is an inflammatory disease in which immune mechanisms interact with metabolic risk factors to initiate, propagate and activate lesions in the arterial wall [2]. About two decades ago, it was widely expected that the treatment of hypercholesterolemia and hypertension would eliminate CADs by the end of the 20th century but this has not been the case. CVDs include coronary heart disease (heart attacks), cerebrovascular disease (stroke), high blood pressure (hypertension), peripheral artery disease, rheumatic heart disease, congenital heart disease, and heart failures [3]. The first two are the foremost causes of death in Africa and the world over. In 2008, about 17.3 million deaths were as a result of cardiovascular diseases. These represented 30% of the global death toll in 2008. Out of this figure, 7.3 million were due to coronary artery disease (Atherosclerosis), 6.2 million were due to stroke and 5.8 million were jointly caused by hypertension, high blood pressure, diabetes, and heart failure. Moreover, Coronary Artery Disease (CAD) is the principal cause of death in both males and females in the low-income and high-income countries. There is, therefore, an urgent need for improved approaches for the treatment of CAD in both developed developing and underdeveloped countries. People in low and middle-income countries are usually more exposed to risk factors of CVDs and do not often benefit from prevention programs as do people in high-income countries

Citation - Reference

All Project Materials Inc. (2020). PRODIGIOSIN ENCAPSULATED POLY LACTIDE-CO-GLYCOLIDE (PLGA)-COATED STENT FOR CORONARY CARDIOVASCULAR INTERVENTIONS. Available at: https://researchcub.info/department/paper-6211.html. [Accessed: ].

PRODIGIOSIN ENCAPSULATED POLY LACTIDE-CO-GLYCOLIDE (PLGA)-COATED STENT FOR CORONARY CARDIOVASCULAR INTERVENTIONS


Delivery Assurance: This Project material is delivered within 15-30 Minutes. Click below to download complete material.


Download Complete Project Material

Call: +2347063298784

Hire a Writer

Department

Search Word Tags:


A Review on prodigiosin encapsulated poly lactide, co, glycolide (plga), coated stent for coronary cardiovascular interventions, disease, coronary, cardiovascular, research journals and thesis, researchcub.info, physical science project topics.
This research focuses on the design of a robust but flexible prodigiosin eluting stent coating for possible coronary cardiovascular implant. When coated with the drug embedded polymer matrix, the stent would be expected to dilate the vessel around the fatty blockages while the drug eluting polymer membrane delivers anti-proliferative drugs over a period of time to prevent the restenosis that otherwise would occur. The goal of this work is to incorporate anti-cancerous drug prodigiosin in the PLGA polymer matrix and then ascertain its release kinetics. In this research, Poly vinyl Pyrrolidone was used as a binder and cross-linker to create adhesion between the metallic stent strut and the drug encapsulated polymer matrix as well as between the polymer and the drug. This work also explores diffusion and degradation phenomena to explain the transport, dissemination, dispersion and absorption of drugs at the interface between the stent and the vessel wall. The expected results will then be discussed for potential applications via the incorporation of these prodigiosin-eluting stents for the treatment of coronary cardiovascular diseases... Click here for more

PRODIGIOSIN ENCAPSULATED POLY LACTIDE-CO-GLYCOLIDE (PLGA)-COATED STENT FOR CORONARY CARDIOVASCULAR INTERVENTIONS - Research Journals and Thesis - Researchcub.info

Excellent and Professional research project topics, ideas and materials Website - researchcub.info

Undergraduate Project Topics, economics project topics, marketing project topics, business administration project topics, engineering project topics, computer science project topics, banking & finance project topics, education project topics, law project topics, sciences project topics, public administration project topics, political science project topics, mathematics project topics, medical science project topics, mass communication project topics, research projects, geology project topics, marketing project topics, agriculture project topics, Browse Thousands of Final Year Project Topics, hire a writer, Research Works and Materials, Project topics and materials in Nigeria, Undergraduate Project Topics, Research Works and Materials, research topics, research project materials, complete project materials, computer science project material, free project topics, complete projects, accounting topics, small business topics, entrepreneurship topics, project materials, Nigerian undergraduate projects, business administration projects, computer science topics and projects, MBA Nigerian project topics, human resources, small businesses, entrepreneurship projects, economics projects, impacts projects, effect projects, university projects, polytechnic projects, investigate projects, political science projects, mass communication projects, project topics, human resource projects, education projects, French topics, project analysis, French projects, project tips, project abstract, project proposals, project bibliography, project reference, project seminar, forex, TSA, treasury single account, currency, naira, devaluation, undergraduate projects, final project research, marketing project topics, statistics project topics, mathematics project topics, statistics, mathematics, research projects, project thesis, labour force theses, NCE, OND, HND, BTECH, BSC, MBA, MSC, English projects, linguistic project topics, Free Project topics and materials in Nigeria, research topics, reseach project materials, computer science project material, free, complete, accounting topics, small business topics, materials, nigeria projects, business administration projects, computer science topics and projects, MBA nigeria project topics, human resources, small business, entrepreneurship projects, economics projects, impact projects, effects projects, training, budgets, ghana, university, polytechnic, browse Free project materials and topics in Nigeria, accounting and finance project materials, business administration project materials and topics, human resources, entrepreneurship, computer science and engineering project materials and topics, Accounting project topics, Accounting project topics and materials, Agricultural Economics Project Topics and Materials, Agricultural Science Projects topics and materials, All Project topics and materials, Architecture Project topics and materials, Aviation project topics and materials, Banking & Finance Projects topics and materials, Biology project and materials, Building project topics and materials, Business Administration & Management Projects topics and materials, Chemical Engineering Project Topics and materials, Civil Engineering Projects topics and materials, Communication & mass communication art project topics and materials, Computer Engineering Project Topics and materials, Computer Science Projects topics and materials, Criminology project topics and materials, Economics Research Projects topics and materials, Education Project Topics and Materials, Electrical Engineering Projects and materials, English Education & English Language Project topics and materials, Food Science project topics and materials, Geology Project Topics and materials, Guidance Counseling Project Topics and materials, History project topics and materials, Home Economics Project Topics and Materials, Human Resource Projects topics and Materials, Industrial Chemistry Projects topics and materials, Insurance Projects topics and materials, Law project topics and materials, Library and information science project topics and materials, Marine and Transport management project topics and materials, Marketing Projects topics and materials, Mathematics project topics and materials, Medical Sciences Project Topics and materials, Microbiology project topics and materials, Nursing and Midwifery project topics, Nursing and Midwifery project topics and materials, Optometry or nursing project topics and materials, Petroleum Engineering project topics and materials, Pharmacy project topics and materials, Philosophy project topics and materials, Photography project topics and materials, Physical and Health Education project topics and materials, Physiology project topics and materials, Political science project topics and materials, Project topics and materials, Psychology project topics and materials, Random project, Religious and Cultural Studies Project Topics and Materials, Sociology and Anthropology Project topics and materials, Sociology Project Topics and materials, Tourism project topics and materials, Vocational education project topics and materials PRODIGIOSIN ENCAPSULATED POLY LACTIDE-CO-GLYCOLIDE (PLGA)-COATED STENT FOR CORONARY CARDIOVASCULAR INTERVENTIONS-disease- coronary- cardiovascular- Research Journals and Thesis | Researchcub.info